Publications from the Comparative Oncology Program
Clinical Trials
- Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs October 2022 (COTC Publication)
- Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs June 2021 (COTC Publication)
Research
- Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas February 2024
- Patterns of metastatic progression and association with clinical outcomes in canine osteosarcoma: A necropsy study of 83 dogs. December 2023
- Large Scale Comparative Deconvolution Analysis of the Canine and Human Osteosarcoma Tumor Microenvironment Uncovers Conserved Clinically Relevant Subtypes. September 2023
- Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans. August 2023
Deep Domain Adversarial Learning for Species-Agnostic Classification of Histologic Subtypes of Osteosarcoma January 2023
- Canine and murine models of osteosarcoma March 2022
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species September 2021
- Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events (VCOG-CTCAE v2) following investigational therapy in dogs and cats June 2021
- Improving human cancer therapy through the evaluation of pet dogs December 2020
- Advanced Cancer Imaging Applied in the Comparative Setting February 2020
- Comparative Molecular Life History of Spontaneous Canine and Human Gliomas February 2020.
Clinical Trials
- NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma December 2018 (COTC Publication)
- A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model PLOS One, February 2016. (COTC Publication)
- Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma PLOS One, June 2015. (COTC Publication)
Research
- A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma. November 2018 (CBTC Publication)
- Consensus recommendations on standardized magnetic resonance imaging protocols for multicenter canine brain tumor clinical trials. May 2018. (CBTC Publication)
- Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug-induced DNA double strand breaks from DNA double strand breaks associated with apoptosis. March 2018
- Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients. May 2016. (CBTC Publication)
Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology. February 2016.
Defining the Value of a Comparative Approach to Cancer Drug Development. December 2015.
Clinical Trials
- Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials PLOS ONE, March 2014. (COTC Publication)
- A Compendium of Canine Normal Tissue Gene Expression PLoS One, May 2011.
- Rapamycin Pharmacokinetic and Pharmacodynamic Realtionships in Osteosarcoma: A Comparative Oncology Study in Dogs. PLoS One, June 2010. (COTC Publication)
- Launching a Novel Preclinical Infrastructure: Comparative Oncology Trials Consortium Directed Therapeutic Targeting of TNFalpha to Cancer Vasculature. PLoS One, March 30, 2009. (COTC Publication)
Research
- The Creation of the Comparative Oncology Trials Consortium Pharmacodynamic Core: Infrastructure for a virtual laboratory. Veterinary Journal, July 2010.
- The Comparative Oncology Trials Consortium: Using Spontaneously Occurring Cancers in Dogs to Inform the Cancer Drug Development Pathway. PLoS Medicine, October 13, 2009.
Guiding the Optimal Translation of New Cancer Treatments from Canine to Human Cancer Patients. Clinical Cancer Research 15:5671-7, September 15, 2009.
- Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics, December 2009
- Translation Of New Cancer Treatments From Pet Dogs To Humans. Nature Reviews Cancer. February 2008.