A phoenix offspring emerging from the ashes of an old liver during regeneration through chromatin-mediated mechanisms.

In this issue of Molecular Cell, Yang and colleagues discover age-dependent increases in broad regions of the repressive histone modification H3K27me3. They also demonstrate partial reversion to younger H3K27me3 patterns and gene expression upon resection of older livers.

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Article: https://www.sciencedirect.com/science/article/pii/S1097276523002496?via%3Dihub