Seminars Archive

Andre Nussenzweig - Wei Yang Virtual Seminar Series

This series is co-sponsored by the National Cancer Institute (NCI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This seminar series is currently on hold. Announcements will be made should it resume in the future. For more information, please contact Sam John at sam.john@nih.gov 

Archived Seminars

We are working on archiving some of our seminars on NCI YouTube. The first one has been posted and is now available:

• Replisome Encounters with Absolute Blocks to Replication

All past seminars are listed below. Note: Not all seminars are recorded.

*Seminar is available on NCI YouTube.

2024 Past Seminars 

Wed 28-Aug  
Title: Proteogenomic insights into multiple myeloma
Speaker: Ryan Young, Stadtman Investigator, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

2023 Past Seminars 

Mon 28-Aug  
FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in meiotic DNA replication and recombination
Speaker: Akira Shinohara, Institute for Protein Research, Osaka University, Suita, Osaka, Japan

2022 Past Seminars 

Mon 14-Nov  
In vivo reduction of RAD51-mediated homologous recombination not only protects against tumorigenesis but triggers premature aging 
Speaker: Bernard S. Lopez, Director of Research Exceptional Class (DRCE) CNRSInstitut Cochin, Université de Paris-Cité, INSERM, CNRS, Paris, France

Mon 7-Nov  
New Principles of Transcription-coupled DNA Repair in Bacteria 
Speaker: Evgeny Nudler, Investigator, Howard Hughes Medical Institute; Julie Wilson Anderson Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY

Mon 31-Oct  
Microbiome control of host immunity 
Speaker: Yasmine Belkaid, NIH Distinguished Investigator, Director NIAID Microbiome Program, Director NIH Center for Human Immunology, Chief Metaorganism Immunology Section and Chief Laboratory of Host Immunity and Microbiome Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

Mon 24-Oct  
Chromatin regulation and genome maintenance by mammalian Sirtuins in aging and disease 
Speaker: Katrin Chua, Department of Medicine, Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Stanford, CA and Geriatric Research Education and Clinical Center, VA Palo Alto Health Care System, Palo Alto, CA

Mon 3-Oct  
Genetic instability from a single S phase after whole-genome duplication 
Speaker: Renata Basto, Biology of Centrosomes and Genetic Instability, Cell Biology and Cancer Unit, Institut Curie, Paris, France

Mon 19-Sept
Towards Uncovering the Regulatory and Functional Complexity of the Mammalian Transcriptome 
Speaker: Thomas Gonatopoulos-Pournatzis, Stadtman Investigator. Head, Functional Transcriptomics Section, RNA Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD 

Mon 29-Aug
Zinc finger genes vs. Retroviruses: a story of combat and cooperation in mammals 
Speaker: Todd Macfarlan, Senior Investigator, Section on Mammalian Development and Evolution, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD  

Mon 18-July
Proteins that interpret genomic signals to stabilise cell identity
Speaker: Adrian Bird, Buchanan Chair of Genetics, Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK

Mon 20-June
Epigenetic deregulation in cancer: mechanisms and functional impact
Speaker: Paola Scaffidi, Senior Group Leader, Cancer Epigenetics Laboratory, The Francis Crick Institute, London, UK

Mon 13-June
How to maintain the repetitive genome
Speaker: Evi Soutoglou, Professor, Genome Damage and Stability Center, School of Life Sciences, University of Sussex, Brighton, UK

Mon 6-June
Cellular aging in S. cerevisiae: A lead into untangling the web of lysosomal homeostasis
Speaker: Dan Gottschling, Head of Research, Calico Life Sciences, South San Francisco, CA

Mon 23-May
Consequences of pathological DNA double strand breaks in neurons
Speaker: Li-Huei Tsai, Director, Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA

CANCELLED Mon 16-May
Microbiome control of host immunity
Speaker: Yasmine Belkaid, NIH Distinguished Investigator, Director NIAID Microbiome Program, Director NIH Center for Human Immunology, Chief Metaorganism Immunology Section and Chief Laboratory of Host Immunity and Microbiome Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

Mon 9-May
Leverging single-cell dynamics to predict fate outcomes
Speaker: Steven Cappell, Stadtman Investigator. Head, Single-Cell Dynamics Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD

Mon 2-May
Therapeutic approaches to target extrachromosomal DNA amplifications in cancer
Speaker: Roel Verhaak, Professor, Florine Deschenes Roux Chair and Associate Director for Computational Biology, The Jackson Laboratory for Genomic Medicine, Farmington, CT

Mon 25-Apr
Expanding our view of genome activation though genomics and imaging approaches 
Speaker: Antonio Giraldez, Chair, Department of Genetics, Yale University School of Medicine, New Haven, CT 

Mon 18-Apr
Understanding the spliceosome: canonical and non-canonical roles in gene regulation
Speaker: Dan Larson, Senior Investigator. Head, Systems Biology of Gene Expression, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 

Mon 11-Apr
You get a methyl group, and you get a methyl group… everybody gets a methyl group
Speaker: Pedro Batista, Stadtman Investigator. Head RNA Metabolism and Epitranscriptomics Unit, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD  

Mon 4-Apr
Activity-dependent DNA repair in Neuronal Plasticity 
Speaker: Elizabeth Pollina, Postdoctoral Fellow, Department of Neurobiology, Harvard Medical School, Boston, MA  

Mon 21-Mar
Impact of transcription on DNA break repair
Speaker: Lee Zou, Professor, Department of Pathology, Harvard Medical School. Scientific Co-Director, Massachusetts General Hospital Cancer Center, Boston, MA

Mon 14-Mar
Noncoding RNA transcription and somatic hypermutation associated mechanisms in B cells during immunity and lymphomagenesis 
Speaker: Uttiya Basu, Professor, Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY

Mon 7-Mar
No speaker scheduled

Mon 28-Feb
Somatic mutation in human brain neurons over development, aging, and degeneration
Speaker: Christopher Walsh, Investigator, Howard Hughes Medical Institute; Chief, Division of Genetics and Genomics, Boston Children’s Hospital; Bullard Professor of Pediatrics and Neurology, Harvard Medical School

Mon 14-Feb
Cohesin-mediated loop extrusion in nuclear organization and gene regulation
Speaker: Elzo de Wit, Group Leader, Division of Gene Regulation, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands 

Mon 7-Feb
Lysosomal stress: Underlying mechanisms and therapeutic potential
Speaker: Toren Finkel, Distinguished Professor of Medicine, Director, Aging Institute of the University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA

Mon 31-Jan
Regulation by genes-within-genes 
Speaker: Gisela Storz, NIH Distinguished Investigator. Associate Scientific Director, Division of Molecular and Cellular Biology, Section on Environmental Gene Regulation, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD  

Mon 10-Jan
Dissecting molecular mechanisms of the unique neuronal epigenome 
Speaker: Harrison Gabel, Assistant Professor of Neuroscience, Washington University in St. Louis, St. Louis, MO

Mon 3-Jan
Nuclear Architecture, Transcription and Chromosomal Translocations 
Speaker: Rafael Casellas, Chief, Laboratory of Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 

2021 Past Seminars 

Mon 20-Dec
Finding your place: Transcription factors as sensors and modifiers of chromatin  
Speaker: Dirk Schubeler, Director, Friedrich Miescher Institute for Biomedical Research. Professor of Molecular Biology, University of Basel, Basel, Switzerland 

Mon 29-Nov
Designing Synthetic Genome Readers/Regulators (SynGRs)
Speaker: Aseem Z. Ansari, Chair, Chemical Biology & Therapeutics, R.J. Ulrich Endowed Chair, St. Jude Children's Research Hospital, Memphis, TN

Mon 22-Nov
Modifying dogma - expansion of mRNA function through unique chemistry
Speaker: Shalini Oberdoerffer, Deputy Chief, Laboratory of Receptor Biology and Gene Expression. Head, RNA Processing in Cellular Development, National Cancer Institute, National Institutes of Health, Bethesda, MD 

Mon 25-Oct
Lassoing histone variants to a fragile site in the cancer epigenome
Speaker: Yamini Dalal, Senior Investigator, Group Director, Chromatin Structure and Epigenetic Mechanisms Group, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 

Mon 27-Sept 
TET methylcytosine oxidases and cancer
Speaker: Anjana Rao, La Jolla Institute for Immunology and Department of Pharmacology, University of California San Diego, La Jolla, CA

Mon 13-Sept 
Long and short range interactions in the nucleus
Speaker: Gary Felsenfeld, NIH Distinguished Investigator, Physical Chemistry Section, Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, MD

Mon 6-Sept 
Programmed DNA-protein cross-link formation during DNA interstrand cross-link repair
Speaker: Daniel Semlow, Assistant Professor of Biochemistry, California Institute of Technology, Pasadena, CA  

Mon 30-Aug
RAGs to repertoire in CD4⁺CD8⁺ thymocytes
Speaker: Michael Krangel, George Barth Geller Professor and Chair, Department of Immunology, Duke University School of Medicine, Durham, NC

Mon 23-Aug
A high-resolution view of Mre11-catalyzed end resection at DNA double-strand breaks
Speaker: Lorraine Symington, Harold S. Ginsberg Professor, Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY

Mon 16-Aug
Epigenetic nucleotides sensitize BRCA deficient cells to PARP inhibitors
Speaker: Kasper Fugger, DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK

Mon 2-Aug
Mechanisms of replication fork degradation  
Speaker: James Dewar, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville TN  

Mon 26-July
Epigenetic mechanisms in early mammalian development  
Speaker: Maria Elena Torres-Padilla, Director of the Institute of Epigenetics and Stem Cells, Helmholtz Zentrum, Munich, Germany

Mon 19-July
Cellular responses to DNA replication stress  
Speaker: Ian Hickson, Center for Chromosome Stability, University of Copenhagen, Denmark

Mon 12-July
Regulation of telomerase in tissue renewal and cancer​   
Speaker: Steven Artandi, Director of the Stanford Cancer Institute, Department of Biochemistry, Stanford University, Stanford, CA

Mon 14-June
ARP2/3 and resection-coupled assembly of DNA repair domains facilitates translocations
Speaker: Jean Gautier, Co-Leader Cancer Genomics and Epigenomics Program, Herbert Irving Comprehensive Cancer Center (HICCC), Professor, Department of Genetics and Development, Institute for Cancer Genetics, Columbia University, New York, NY

Mon 7-June 
Quantitative in situ imaging of nuclease-triggered DNA repair 
Speaker: John Stamatoyannopoulos, Department of Genome Sciences and Medicine, University of Washington and Scientific Director, Altius Institute for Biomedical Sciences, Seattle, WA

Mon 31-May
No speaker scheduled

Mon 24-May
Chromatin Loop Extrusion Plays  Fundamental Roles in Antibody V(D)J and Class Switch Recombination 
Speaker: Fred Alt, HHMI Investigator, Director, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Charles A. Janeway Professor of Pediatrics and Professor of Genetics, Harvard Medical School, Boston, MA

Mon 17-May
Cellular responses to DNA double-strand breaks: mechanistic insights and clinical applications
Speaker: Steve Jackson, Professor, Head of Cancer Research UK Laboratories, The Gurdon Institute, University of Cambridge, Cambridge, UK

Mon 10-May
Replication damage: allosteric control of PCNA K164 (de)ubiquitination 
Speaker: Titia Sixma, Group Leader, Biochemistry Division and Oncode Institute, Netherlands Cancer Institute, Amsterdam, Netherlands

Mon 3-May
Chromosome and Chromatin dynamics at DNA Double Strand breaks 
Speaker: Gaelle Legube, Principal Investigator, Chromatin and DNA repair group, CBI (Centre De Biologie Integrative), CNRS- University of Toulouse, Toulouse, France

Mon 26-Apr
Dealing with DNA damage during replication
Speaker: Helle Ulrich, Scientific Director, Institute of Molecular Biology (IMB), Professor, Faculty of Biology, Johannes Gutenberg University, Mainz, Germany

Mon 19-Apr 
Breaking symmetry - Assymetric histone inheritance 
Speaker: Xin Chen, Department of Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD

Mon 12-Apr
Epigenome maintenance in response to DNA damage 
Speaker: Sophie Polo, Junior Group Leader, Epigenetics & Cell Fate Centre, University of Paris, Paris, France

Mon 5-Apr
Chromatin directed mechanisms of DNA repair
Speaker: Roger Greenberg, Department of Cancer Biology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Mon 29-Mar
Insights into chromatin replication revealed by DNA strand-specific sequencing methods
Speaker: Zhiguo Zhang, Professor of Epigenomics and Molecular Biology in Departments of Pediatrics, Genetics and Development and the Institute of Cancer Genetics, Columbia University, New York, NY

Mon 22-Mar
Make a break or unwind: Control of structure-specific endonucleases and new functionalities of SLX4
Speaker: Pierre-Henri Gaillard, Group Leader at Cancer Research Centre of Marseille, Marseille, France

Mon 15-Mar
A tale of two genomes: DNA repair in the mitochondria and the nucleus 
Speaker: Agnel Sfeir, Member, Molecular Biology Program, Sloan Kettering Institute, MSKCC, New York, NY 

Mon 8-Mar
Fidelity and infidelity of DNA repair 
Speaker: Jim Haber, Professor of Biology and Director, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA

Mon 1-Mar
Cutting DNA is risky business: the dark side of topoisomerases
Speaker: Sue Jinks-Robertson, Mary Bernheim Distinguished Professor, Dept. of Molecular Genetics & Microbiology, Duke University, Durham, NC.

Mon 22-Feb
Regulation of Replication Timing and Chromosome Architecture
Speaker: David Gilbert, Senior Investigator, San Diego Biomedical Research Institute (SDBRI), La Jolla, CA & the Department of Biological Science, Florida State University, Tallahassee, FL

Mon 15-Feb
No speaker scheduled

Mon 8-Feb
Mining synthetic lethality networks for new DNA repair biology
Speaker: Dan Durocher, Senior Investigator, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

Mon 1-Feb
Chromosome dynamics after a double-strand break induced by meganuclease, CRISPR-Cas9 or TALEN
Speaker: Rodney Rothstein, Professor of Genetics & Development and Systems Biology, Columbia University Irving Medical Center, New York, NY

Mon 25-Jan
Ribonucleotide Excision Repair - Genome Instability, Mutagenesis, and Inflammation
Speaker: Andrew Jackson, Professor of Human Genetics, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK

Mon 18-Jan
Humanizing the Yeast Origin Recognition Complex
Speaker: Bik-Kwoon Tye, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong and the Department of Molecular Biology & Genetics, Cornell University, Ithaca, NY

Mon 11-Jan
The Mechanism of Replication-Coupled DNA Protein Cross-Link Repair
Speaker: Johannes Walter, Howard Hughes Medical Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA

Mon 4-Jan
Large Deletions, Small Trouble?
Speaker: Michael Kosicki, Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA

2020 Past Seminars

Mon 28-Dec
DNA mismatch repair: mechanisms and therapeutic potential
Speaker: Guo-Min Li, Professor of Radiation Oncology and Director of the Reece A. Overcash Jr. Center for Research on Colon Cancer, University of Texas SouthWestern, Dallas, TX 

Mon 21-Dec
RADX regulates RAD51 at replication forks to maintain genome stability
Speaker: David Cortez, Richard Armstrong Professor, Vanderbilt University School of Medicine, Department of Biochemistry, Nashville, TN

Mon 14-Dec
No speaker scheduled

Mon 7-Dec
No speaker scheduled

Wed 2-Dec** Please note that this is a Wednesday seminar starting at 11AM EST
Single molecule studies of homologous recombination
Speaker: Eric Greene, Professor, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY

Mon 30-Nov
No speaker scheduled

Mon 23-Nov
No speaker scheduled

Mon 16-Nov
Regulating two branches the DNA damage response
Speaker: Xiaolan Zhao, Member, Molecular Biology Department, Memorial Sloan Kettering Cancer Center, New York, NY   

Mon 9-Nov
*Replisome Encounters with Absolute Blocks to Replication
Speaker: Michael Seidman, Chief, Section on Gene Targeting, Laboratory of Molecular Gerontology, National Institute of Aging, NIH, Baltimore, MD

Mon 2-Nov
Holding it together while avoiding mistakes: mechanistic insights into non-homologous end joining
Speaker: Joseph Loparo, Associate Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 

Mon 26-Oct
Epigenetic Basis of Cellular Heterogeneity
Speaker: Keji Zhao, Center Director, Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, NIH, Bethesda, MD

Mon 19-Oct
DNA Reaction Intermediates in Living Cells
Speaker: Susan Rosenberg, Professor, Departments of Molecular & Human Genetics, Biochemistry & Molecular Biology & Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX

Mon 12-Oct
No speaker scheduled

Mon 5-Oct
No speaker scheduled

Mon 28-Sept
Computational analysis of thousands of cancer genomes to understand mutational processes
Speaker: Núria López-Bigas, Ph.D., ICREA Research Professor, Barcelona Biomedical Genomics Lab, Institute for Research in Biomedicine (IRB), Barcelona, Spain

Mon 21-Sept
Epigenomic Regulation of Enhancers: from Adipogenesis, Development to Cancer
Speaker: Kai Ge, Ph.D., Senior Investigator and Section Chief, Adipocyte Biology & Gene Regulation Section, NIDDK, NIH, Bethesda, MD

Mon 14-Sept
No speaker scheduled

Wed 9-Sept ** Please note that this is a Wednesday seminar starting at 11AM EDT **
Genome Instability Mediated by Trinucleotide Repeats In Dividing and Non-dividing Cells
Speaker: Sergei Mirkin, White Family Chair in Biology, Department of Biology, Tufts University, Medford, MA 

Mon 7-Sept
No speaker scheduled

Mon 31-Aug
The Dark Side of DNA Repair: The Mechanism of Repeat Expansion Responsible for the Fragile X-related Disorders
Speaker: Karen Usdin, Gene Structure and Disease Section, Deputy Chief, Laboratory of Cell and Molecular Biology, NIDDK, NIH, Bethesda, MD

Mon 24-Aug
Resolution of Topoisomerase DNA-protein crosslinks
Speaker: Scott Williams, Head - Structural Cell Biology Group, Deputy Chief - Genome Integrity & Structural Biology Laboratory, NIEHS, NIH, North Carolina

Mon 17-Aug
The DREAM complex prevents DNA end resection and initiation of HR in G0/G1 phase of the cell cycle
Speaker: Bo-Ruei Chen, Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham,  Birmingham, AL

Mon 10-Aug
Recent progress in understanding eukaryotic DNA replication fidelity
Speaker: Thomas Kunkel, DNA Replication Fidelity Group, Genome Integrity & Structural Biology Lab, NIEHS, NIH, Research Triangle Park, NC

Mon 3-Aug
No speaker scheduled

Mon 27-July
DNA Strand Breakage and Human Genetic Disease
Speaker: Keith Caldecott, Professor of Biochemistry and Deputy Director, Genome Damage and Stability Centre, University of Sussex, UK

Mon 20-July
The role of nuclear re-location in promoting restart of collapsed replication forks and preventing genome instability
Speaker: Catherine Freudenreich, Ph.D., Professor and Chair, Department of Biology; Member, Program in Genetics; Tufts University, MA

Mon 13-July
Loss vs Inhibition – From DNA-PK to PARP1&2
Speaker: Shan Zha, M.D. Ph.D. Associate Professor, Department of Pediatrics, Institute for Cancer Genetics, Columbia University, New York, NY

Mon 6-July
Repair of AID-initiated DNA lesions in B cells
Speaker: Feilong Meng, Ph.D., Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China 

Mon 29-June
Break-Induced Replication - unusual mode of DNA synthesis leading to genomic instability
Speaker: Anna Malkova, Ph.D., Professor of Biology, Department of Biology, University of Iowa, Iowa City, Iowa

Mon 22-June
The Causes and Consequences of Replication Stress:  HLTF and Replication Stress Resistance
Speaker: Karlene Cimprich, Ph.D., Professor of Chemical and Systems Biology, Stanford University School of Medicine, CA

Mon 15-June
Structural mechanism of DNA end sensing and processing by Mre11-Rad50
Speaker: Karl-Peter Hopfner, Ph.D., Department of Biochemistry and Gene Center, Ludwig-Zoom Maximilians-University, Munich, Germany

Mon 8-June
ATM loss and cerebellar neurodegeneration
Speaker: Tanya Paull, Ph.D., Professor, Department of Molecular Biosciences, University of Texas at Austin, TX

Wed 20-May
DNA damage in immunity and cancer
Speaker: Alberto Martin, Ph.D., Department of Immunology, University of Toronto, Toronto, Canada

Mon 18-May
The function of nucleases in homologous recombination
Speaker: Peter Cejka, Ph.D., Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Switzerland 

Mon 11-May
Promiscuous synthesis during repair of chromosome breaks: what goes in, when, and why 
Speaker: Dale Ramsden, Ph.D., Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC