Nathanael D. Pruett, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10-CRC, Room 3-5888
- Bethesda, MD 20892-1201
- 240-858-3736
- nathanael.pruett@nih.gov
RESEARCH SUMMARY
Dr. Pruett’s research focuses on elucidating the oncogenic regulatory mechanisms underlying the establishment and progression of mesothelioma focusing on the role inflammation as a causative signaling pathway. To do this, he is developing oncogenic models with which to evaluate contributing signal transduction pathways and resulting gene expression patterns with the ultimate goal of identifying potential clinically translatable targets.
Areas of Expertise
Nathanael D. Pruett, Ph.D.
Research
Dr. Pruett’s research focuses on elucidating the oncogenic regulatory mechanisms underlying the establishment and progression of mesothelioma focusing on the role inflammation as a causative signaling pathway. To do this, he is developing oncogenic models with which to evaluate contributing signal transduction pathways and resulting gene expression patterns with the ultimate goal of identifying potential clinically translatable targets.
Publications
The Energetics and Physiological Impact of Cohesin Extrusion
In vitro experimental models of mesothelioma revisited
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation
A genome-wide map of CTCF multivalency redefines the CTCF code
Biography
Nathanael D. Pruett, Ph.D.
Dr. Pruett received his Ph.D. degree in Biomedical Sciences from the Medical University of South Carolina in 2011 where his studies focused on cardiovascular biology and developmental biology. He joined the National Institutes of Health as a postdoctoral trainee in the Laboratory of Molecular Immunogenetics headed by Dr. Raphael Casellas, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Genomics and Immunity Section. Here Dr. Pruett worked to advance the goal of the lab to better understand the genetic and molecular pathways that drive the immune response under normal and pathological conditions. His contributions were recognized in 2014 by being presented with the NIH Director’s Award for his involvement in establishing and executing the NIH Mouse Regulome Project. In January 2017 he joined Dr. Hoang’s lab as a Research Biologist.