Sam John, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 1108
- Bethesda, MD 20814-4254
- 240-760-7601
- 240-541-4489
- sam.john@nih.gov
RESEARCH SUMMARY
Dr. John's research interests have focused on understanding how the organization of the genome is regulated and linked to regulatory processes. As a post-doctoral fellow, he developed platforms for the purification and characterization of novel multi-subunit chromatin modifying and remodeling activities. During his tenure as a staff scientist, Dr. John developed cutting-edge and innovative protocols to map chromatin structure by coupling traditional biochemical procedures with high throughput genome-wide approaches to identify regulatory regions globally. His contributions led to some of the first maps that detailed regulatory regions and helped define the accessible chromatin landscape and the regulatory language encoded in transcription factor footprints across the human genome. These studies have laid the foundation for a deeper understanding of sequence information in both physiological and pathological states.
Areas of Expertise
Sam John, Ph.D.
Biography
Sam John, Ph.D.
Dr. John received his Ph.D. from George Washington University and was a post-doctoral fellow with Dr. Jerry Workman at Penn State University. He was a staff scientist, first with Dr. Gordon Hager in the intramural research program of the National Institutes of Health and then with Dr. John Stamatoyannopoulos at the University of Washington in Seattle. Since 2013, he has been the senior technical laboratory manager for the Laboratory of Genome Integrity in the National Cancer Institute.