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Shan Li, Ph.D.

Shan Li, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Shan Li's research focuses on deciphering the encryption of the gene regulatory code in eukaryotes, and identify the linkage between regulatory element sequence variations and diseases, especially cancer.

Areas of Expertise

Computational Biology
Gene Regulation
Genomics
Machine Learning
Cancer Genomics

Publications

Selected Key Publications

Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation

Li S, Kvon EZ, Visel A, Pennacchio LA, Ovcharenko I.
Genome Biol. 20(1): 140, 2019. [ Journal Article ]

Quantifying deleterious effects of regulatory variants

Li S, Alvarez RV, Sharan R, Landsman D, Ovcharenko I.
Nucleic Acids Res. 45(5): 2307-2317, 2017. [ Journal Article ]

Human Enhancers Are Fragile and Prone to Deactivating Mutations

Li S, Ovcharenko I.
Mol Biol Evol. 32(8): 2161-80, 2015. [ Journal Article ]

De novo human brain enhancers created by single-nucleotide mutations

SHAN LI, SRIDHAR HANNENHALLI, IVAN OVCHARENKO
Science Advances. Vol 9, Issue 7: 2023.
Full-Text Article
[ Journal Article ]

SNPDelScore: combining multiple methods to score deleterious effects of noncoding mutations in the human genome

Alvarez RV, Li S, Landsman D, Ovcharenko I.
Bioinformatics. 34(2): 289-291, 2018. [ Journal Article ]