Breadcrumb

Sri Krishna

Sri Krishna, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Stadtman Investigator
Surgery Branch

RESEARCH SUMMARY

Dr. Krishna has a broad background in human immunology with expertise in developing cellular immunotherapies against metastatic solid tumors. His research is focused on discovering and studying antitumor T cells including those targeting neoantigens, antitumor T cell receptors, human T cell differentiation states, and immune resistance by human tumors.

Areas of Expertise

T Cell Dysfunction
Neoantigens
Adoptive Cell Therapy

Publications

Selected Key Publications

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Krishna S*, Lowery FJ*, Copeland AR, Bahadiroglu E, Mukherjee R, Jia L, Anibal JT, Sachs A, Adebola SO, Gurusamy D, Yu Z, Hill V, Gartner JJ, Li YF, Parkhurst M, Paria B, Kvistborg P, Kelly MC, Goff SL, Altan-Bonnet G, Robbins PF, Rosenberg SA. * Co-first authors
Science. 370: 6522 : 1328-1334, 2020.
Full-Text Article
[ Journal Article ]

Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

Lowery FJ#, Krishna S#, Yossef R, Parikh NB, Chatani PD, Zacharakis N, Parkhurst MR, Levin N, Sindiri S, Sachs A, Hitscherich KJ, Yu Z, Vale NR, Lu YC, Zheng Z, Jia L, Gartner JJ, Hill VK, Copeland AR, Nah SK, Masi RV, Gasmi B, Kivitz S, Paria BC, Florentin M, Kim SP, Hanada KI, Li YF, Ngo LT, Ray S, Shindorf ML, Levi ST, Shepherd R, Toy C, Parikh AY, Prickett TD, Kelly MC, Beyer R, Goff SL, Yang JC, Robbins PF, Rosenberg SA. # Co-corresponding and co-first authors
Science. 375: 6583 : 877-884, 2022.
Full-Text Article
[ Journal Article ]

Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers

Yossef R*ϯ, Krishna S*ϯ, Sindri S, Lowery FJ, Copeland AR, Gartner JJ, Parkhurst, MR, Parikh NB, Hitscherich KJ, Levi ST, Chatani PD, Zacharakis N, Levin N, Vale NR, Nah SK, Hll VK, Ray S, Bera A, Levy L, Jia L, Kelly MC, Goff SL, Robbins PF, Rosenberg SA ϯ. Phenotypic signaatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers. Cancer Cell, Dec, 2023 (*Co-first, ϯ Co-corresponding authors)
Cancer Cell. 41:12: 2154-2165.e5, 2023.
Full-Text Article
[ Journal Article ]

Human Papilloma Virus Specific Immunogenicity and Dysfunction of CD8+ T Cells in Head and Neck Cancer

Krishna S, Ulrich P, Wilson E, Parikh F, Narang P, Yang S, Read AK, Kim-Schulze S, Park JG, Posner M, Wilson Sayres MA, Sikora A, Anderson KS
Cancer Research. 78: 21: 6159-6170, 2018.
Full-Text Article
[ Journal Article ]

TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes

Chowell D*, Krishna S*, Becker PD, Cocita C, Shu J, Tan X, Greenberg PD, Klavinskis LS, Blattman JN, Anderson KS. * Co-first authors
Proceedings of the National Academy of Sciences of USA. 112: 14: E1754-62, 2015.
Full-Text Article
[ Journal Article ]

Team

Postbaccalaureate Fellow
Victoria Dulemba, B.S.
Dinerman
Immunotherapy Clinical Fellow
Aaron Dinerman, M.D.
emery.hoos@nih.gov
Pre-doctoral IRTA (Graduate Student)
Emery A Hoos, B.S.
Postdoctoral Visiting Fellow
Grace Atrill, Ph.D.