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Yuichi Machida

Yuichi Machida, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Senior Investigator
Developmental Therapeutics Branch

RESEARCH SUMMARY

Dr. Machida is a molecular biologist investigating the effects of DNA damage on DNA replication. His current research focuses on DNA-protein crosslinks (DPCs), a type of DNA damage where proteins are accidentally crosslinked to genomic DNA. Dr. Machida’s group uses molecular and cell biology techniques to elucidate DPC repair mechanisms and employs mouse genetics to study tumori formation caused by unrepaired DPCs.

Areas of Expertise

DNA Repair
DNA Replication
Genomic Instability
Proteases

Publications

Selected Key Publications

Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes

Palani S, Machida Y, Alvey JR, Mishra V, Welter AL, Cui G, Bragantini  B, Botuyan MV, Cong ATQ, Mer G, Schellenberg MJ & Machida YJ
Nature Commun. 15(1): 2064, 2024.
Full-Text Article
[ Journal Article ]

Functions and evolution of FAM111 serine proteases

Welter AL, Machida YJ.
Front Mol Biosci. 9: 1081166, 2022.
Full-Text Article
[ Journal Article ]

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Kojima Y, Machida Y, Palani S, Caulfield TR, Radisky ES, Kaufmann SH, Machida YJ.
Nat Commun. Mar 12;11(1): 1318, 2020.
Full-Text Article
[ Journal Article ]

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ.
Nucleic Acids Res. May 5;45(8): 4564-4576, 2017.
Full-Text Article
[ Journal Article ]

Spartan deficiency causes genomic instability and progeroid phenotypes

Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ.
Nat Commun. Dec 11;5: 5744, 2014.
Full-Text Article
[ Journal Article ]

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Team

Biologist
Yuka Machida
Predoctoral Fellow
Allie Welter
Postdoctoral Fellow (Visiting)
Shraddheya Patel, Ph.D.
POSTDOCTORAL FELLOW (VISITING)
Sudhaker Dharavath, Ph.D.

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