Stephanie L. Goff, M.D.

Center for Cancer Research
National Cancer Institute

Building 10 - Hatfield Clinical Research Center, Room 3-5930
Bethesda, MD 20892
240-760-6214
stephanie.goff@nih.gov

Senior Research Physician

Surgery Branch

Head, Clinical Operations for Surgery Branch cGMP Facilities

Team Member Of:

Chief

Steven A. Rosenberg, M.D., Ph.D.

SAR@nih.gov

RESEARCH SUMMARY

As a member of Dr. Rosenberg's senior staff, I share responsibility for the care and management of patients receiving cell-based immunotherapy for the treatment of metastatic solid tumors on protocols established by the Surgery Branch. These patients have a variety of malignancies (melanoma, ovarian, breast, gastrointestinal, sarcoma, etc.). My research is two-pronged: (1) focused on the use of adoptive cell transfer in patients with metastatic breast cancer, based on a system of identifying non-synonymous mutations within an individual tumor and evaluating the ability of that patient's lymphocytes to recognize the mutation in vitro and (2) further understanding therapeutic options for patients with treatment-refractory melanoma.

Areas of Expertise

Melanoma/Skin Cancer

Immunotherapy

Breast Cancer

Surgical Oncology

Clinical Trials
Research
Publications
Biography
News

Open - Recruiting

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Protocol ID
IRB001827

Investigator

Stephanie L. Goff, M.D.

Referral Contacts

NCI Surgery Branch Immunotherapy Recruitment Center

866-820-4505
Open - Recruiting

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

Protocol ID
000354

Investigator

Stephanie L. Goff, M.D.

Referral Contacts

NCI Surgery Branch Immunotherapy Recruitment Center

Research

We are evaluating tumor-infiltrating lymphocytes in tumors removed from patients with metastatic breast cancer, developing methods to explore adoptive cell transfer for this patient population. In addition to genomic studies to evaluate non-synonymous mutations, we are also exploring the development of T-cell receptors for future opportunities to explore gene-engineered peripheral blood lymphocytes (PBL) for clinical use.

Publications

Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma

Seitter SJ, Sherry RM, Yang JC, Robbins PF, Shindorf ML, Copeland AR, McGowan CT, Epstein M, Shelton TE, Langhan MM, Franco Z, Danforth DN, White DE, Rosenberg SA, Goff SL.

Clinical Cancer Research. 27/19: 5289-5298, 2021.

Full-Text Article

[ Journal Article ]

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL, Feldman SA.

Nature Medicine. 24(6): 724-730, 2018. [ Journal Article ]

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

Goff SL, Dudley ME, Citrin DE, Somerville RP, Wunderlich JR, Danforth DN, Zlott DA, Yang JC, Sherry RM, Kammula US, Klebanoff CA, Hughes MS, Restifo NP, Langhan MM, Shelton TE, Lu L, Kwong ML, Ilyas S, Klemen ND, Payabyab EC, Morton KE, Toomey MA, Steinberg SM, White DE, Rosenberg SA

J Clin Oncol. 2016 May 23. pii: JCO667220. [Epub ahead of print]: [ Journal Article ]

Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer

Assadipour Y, Zacharakis N, Crystal JS, Prickett TD, Gartner JJ, Somerville RPT, Xu H, Black MA, Jia L, Chinnasamy H, Kriley I, Lu L, Wunderlich JR, Zheng Z, Lu YC, Robbins PF, Rosenberg SA, Goff SL, Feldman SA

Clin Cancer Res. 2017. [ Journal Article ]

Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion

Goff SL, Johnson LA, Black MA, Xu H, Zheng Z, Cohen CJ, Morgan RA, Rosenberg SA, Feldman SA.

Cancer Immunol Immunother. 59: 1551-60, 2010. [ Journal Article ]

Biography

Senior Research Physician

Stephanie L. Goff, M.D.

Stephanie Goff is a surgeon on the senior staff of the Surgery Branch of the National Cancer Institute at the NIH. Her research interests include adoptive cell therapy for the treatment of solid tumors, building on the backbone of success in patients with metastatic melanoma to investigate the strategy in patients with metastatic breast cancer. Her publications range from analysis of early trials of checkpoint blockade to genetic modifications of T-cell receptors.

She is an honors graduate of the Georgia Institute of Technology (Mechanical Engineering) and obtained her MD at the University of South Florida in Tampa. After training in tumor immunology under Dr. Steven Rosenberg, Dr. Goff completed her general surgery residency at Columbia University followed by a surgical oncology fellowship at the combined Dana-Farber Cancer Institute/Brigham and Women’s Hospital/Massachusetts General Hospital program.

Awards and Honors

2020 NIH Director's Award - The Alan S. Rabson Award for Clinical Care

2020 NIH Clinical Center - Staff Clinician of the Year

2019 NCI Director's Award of Merit