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Clinical Trials

High magnification micrograph of a clear cell renal cell carcinoma

Combination therapy in patients with advanced kidney cancer found to be highly effective

A phase III international clinical trial that tested the combination therapy of nivolumab and cabozantinib in patients with advanced, untreated renal-cell carcinoma yielded promising results.

Clinical trial investigates vaccine to treat recurrent respiratory papillomatosis after surgery

Scott M. Norberg, D.O., Assistant Research Physician in the Genitourinary Malignancies Branch, is leading a study of PRGN-2012, an experimental therapeutic vaccine for adults with recurrent respiratory papillomatosis (RRP). RRP is a rare disorder caused by human papillomavirus.

New trial evaluates immunotherapy combinations in adults with advanced small bowel and colorectal cancers

Julius Strauss, M.D., Assistant Research Physician in the Laboratory of Tumor Immunology and Biology, is leading a clinical trial evaluating a combination of immunotherapy drugs to see if they can shrink advanced tumors of the small bowel, colon and rectum.

Clinical trial evaluates combination therapy for men with metastatic prostate cancer

Ravi A. Madan, M.D., Senior Clinician in the Genitourinary Malignancies Branch, is leading a study of an experimental treatment for men with two types of prostate cancer: one type that responds to hormone therapy and one that doesn’t.

Clinical trial studies immunotherapy combination for recurrent thymoma and thymic carcinoma

Thymic epithelial tumors (TETs) are rare cancers that originate from the cells of the thymus, a small organ that sits in the chest between the lungs and above the heart. Arun Rajan, M.D., Senior Clinician in the Thoracic and GI Malignancies Branch, is leading a clinical trial of a therapy for thymoma and thymic carcinoma that has returned after chemotherapy and cannot be treated with surgery.

Clinical trial studies therapy for relapsed/refractory T-cell malignancies

Milos Miljkovic, M.D., M.Sc., Assistant Research Physician in the Lymphoid Malignancies Branch, is leading a study of a 4-drug combination treatment strategy using romidepsin, oral 5-azacitidine, dexamethasone and lenalidomide for T-cell malignancies (TCMs). Researchers are seeking to determine the safety, side effects, and best dose of this 4-drug combination for people with relapsed/refractory TCM.

Study evaluates, treats, and follows patients with gastrointestinal stromal tumors

More than half of all gastrointestinal stromal tumors (GISTs) start in the stomach, but they can start anywhere in the GI tract. Andrew M. Blakely, M.D., Assistant Research Physician in the Surgical Oncology Program, is leading a study of GIST that could benefit current and future patients.

New clinical trial studies immunotherapy combination for metastatic breast cancer

Fatima Karzai, M.D., Associate Research Physician in the Genitourinary Malignancies Branch, is leading a study in adults with breast cancer that has spread to other places in the body. Researchers want to see if a combination of four drugs, which includes immunotherapy, can shrink the tumors of metastatic breast cancer.

Clinical trial studies therapy for adults with BRAF-mutant hairy cell leukemia

Adults with BRAF-mutant hairy cell leukemia, that did not respond to or came back after treatment, may be eligible to participate in a clinical trial at the NIH Clinical Center. Researchers want to see if combining encorafenib and binimetinib has an improved response rate than other drugs previously used to treat HCL.

Immunotherapy combination tested for advanced/metastatic solid tumors

Adults with locally advanced or metastatic solid tumors that cannot be treated with surgery may be eligible to participate in a clinical trial at the NIH Clinical Center. James L. Gulley, M.D., Ph.D., Chief of the Genitourinary Malignancies Branch, is leading a study exploring several different combinations of immunotherapies to see if they improve responses in people with cancer.

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Clinical Trials