Clinical Trials

Clinical trial studies six-drug combination aimed at relapsed/refractory B-cell lymphoma

Christopher J. Melani, M.D., Assistant Research Physician in the Lymphoid Malignancies Branch, is leading a study to see whether a combination of six drugs is safe and can help people with both aggressive and indolent B-cell lymphoma.

New study tests therapy in patients with hemorrhagic cystitis after bone marrow transplant

Jennifer A. Kanakry, M.D., Associate Research Physician in the Experimental Transplantation and Immunotherapy Branch, is leading CCR’s participation in a study of a drug, Viralym-M, that targets six viruses that can cause hemorrhagic cystitis (HC) in people who have had a hematopoietic cell transplant. Researchers are most interested in Viralym-M’s ability to clear the symptoms of HC faster than a placebo and evaluating Viralym-M’s effect on five other viruses.

Clinical trial studies immunotherapy and radiation for pancreatic cancer

Fewer than 10 percent of people with pancreatic cancer can have surgery, which offers the best chance of a cure. Udo Rudloff, M.D., Ph.D., Senior Investigator in the Pediatric Oncology Branch, is leading a study testing a combination of immunotherapy and radiation for people with advanced pancreatic cancer to shrink tumors and make surgery possible.

A conversation with CCR immunotherapy experts

June is Immunotherapy Awareness Month. We asked members of the Surgery Branch about their work with immunotherapy as they continue to make important advances in this growing field.

Clinical trial evaluates COVID-19 vaccine in adults in treatment for cancer

Adults with hematologic malignancies or solid tumors may be eligible to participate in a new clinical trial at the NIH Clinical Center. Elad Sharon, M.D., M.P.H., Senior Investigator at the National Cancer Institute, is leading a study to assess the effects of the Moderna COVID-19 vaccine (mRNA-1273) in adults undergoing treatment for various types of cancer.

Personalized approach to prostate cancer diagnosis could mean less invasive biopsies

Systematic and MRI-guided biopsies can each find cancers that the other technique can miss — but not everyone needs both. According to a new analysis, magnetic resonance imaging can be used to determine which biopsy approach is appropriate for an individual.

Stem cell transplant after CAR T-cell therapy effective for young leukemia patients

In a clinical trial, CCR physician-scientists found that long-term survival for young patients with B-cell acute lymphoblastic leukemia was significantly better for those who received CD19-CAR T-cell therapy followed by a stem cell transplant. As a result of these findings, use of stem cell transplant is now recommended following CAR T-cell therapy.

Manufactured CAR T cells ready for infusion into a patient

FDA approves BCMA-targeted CAR T-cell therapy for multiple myeloma

The Food and Drug Administration approved idecabtagene vicleucel (Abecma) for people with multiple myeloma that has not responded to or has returned after at least four different prior cancer treatments. The approval is based, in part, on earlier clinical work led by James N. Kochenderfer, M.D., Senior Investigator in the Surgery Branch.

Brigitte Widemann named a Top Ten Clinical Research Achievement Awardee

Brigitte C. Widemann, M.D., Chief of the Pediatric Oncology Branch, has been named a Top Ten Clinical Research Achievement Awardee by the Clinical Research Forum, and she was awarded a Distinguished Clinical Research Achievement Award for her study “Selumetinib in Children with Inoperable Plexiform Neurofibromas.”

FDA grants orphan drug designation to PRGN-2012 for recurrent respiratory papillomatosis

The Food and Drug Administration has granted orphan drug designation to PRGN-2012 immunotherapy for use in patients with recurrent respiratory papillomatosis.

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