Clinical Trials

Young male doctor with an older male patient.

Clinical trial researches drug therapy for prostate cancer

A clinical trial led by William Douglas Figg Sr., Pharm.D., Senior Investigator in the Genitourinary Malignancies Branch is researching a drug therapy for advanced prostate cancer.

Clinical trial researching stem cell therapy for acute myeloid leukemia

A clinical trial led by Nirali N. Shah, M.D., M.H.Sc., Lasker Clinical Research Scholar in the Pediatric Oncology Branch, is researching hematopoietic stem cell transplants and therapy for acute myeloid leukemia.

Clinical trial researching chemotherapy for bile duct cancer

A clinical trial led by Jonathan M. Hernandez, M.D., Investigator in the Surgical Oncology Program, is researching chemotherapy for liver-only cholangiocarcinoma.

Clinical trial researching therapy for blood cancers

A clinical trial led by Christopher Kanakry, M.D., Lasker Clinical Research Scholar in the Center for Immuno-Oncology, is researching blood stem cell transplants for blood cancers such as leukemias or lymphomas.

Clinical trial researching CAR T-cell therapy for leukemia and lymphoma

A clinical trial led by Nirali N. Shah, M.D., M.H.Sc., Lasker Clinical Research Scholar in the Pediatric Oncology Branch, is researching CAR T-cell therapy for leukemias and lymphomas.

Clinical trial researching therapy for aggressive gliomas

A clinical trial led by Sadhana Jackson, M.D., Adjunct Investigator in the Pediatric Oncology Branch, is researching a drug therapy for diffuse midline gliomas, a type of aggressive brain tumor.

Clinical trial researching therapy for HIV-associated blood cancers

A clinical trial led by Kathryn A. Lurain, M.D., M.P.H., Assistant Research Physician in the HIV and AIDS Malignancies Branch, is researching a combination drug therapy for HIV-associated B-cell non-Hodgkin lymphomas.

A doctor sits at a table speaking with a patient.

Clinical trial researches combination drug therapy for B-cell lymphoma of the central nervous system

A clinical trial led by Mark Roschewski, M.D., Senior Clinician in the Lymphoid Malignancies Branch, is researching a therapy for B-cell lymphoma of the central nervous system.

Immunohistochemical staining of a human brain metastasis.

First clinical trial testing a prevention for breast cancer metastasis to the brain yields encouraging results

When breast cancer metastasizes to the brain, new tumors usually develop even after treatment. But recurrence was low among women who received low-dose temozolomide with T-DM1 in a phase I clinical trial.

Normally, tumor cells evade T cells by expressing a checkpoint protein known as PD-L1 (left). Atezolizumab (Tecentriq) binds to PD-L1 and blocks it from binding to another checkpoint protein, PD-1 (right). This helps T cells regain their ability to kill tumor cells.

NCI clinical trial leads to atezolizumab approval for advanced alveolar soft part sarcoma

NCI and CCR researchers have played an instrumental role in identifying the first treatment approved for advanced alveolar soft part sarcoma. The immunotherapy drug atezolizumab (Tecentriq) was approved by the U.S. Food and Drug Administration for the treatment of adults and children two years of age and older with alveolar soft part sarcoma that has spread to other parts of the body or cannot be removed by surgery. The CCR Pediatric Oncology Branch provided treatment and care for all trial patients under 18 years old, making this the first approval for atezolizumab in children.

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