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Joe T. Nguyen

Joe T. Nguyen, D.D.S., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Physician-Scientist Early Investigator
Surgical Oncology Program
NIH Distinguished Scholar

RESEARCH SUMMARY

Head and Neck Cancer (HNC) patients frequently exhibit amplifications and mutations within the PI3K/mTOR signaling pathway. The Nguyen Laboratory is dedicated to uncovering the intricate link between metabolism and its influence on the tumor immune microenvironment using advanced CRISPR/Cas9 gene editing, spatial multiomics bioinformatics analysis, molecular biology techniques. Through insights derived from patient data, we strive to enhance the accuracy of pre-clinical HNC models and drive our understanding of the pathobiology for the development of novel therapeutics to improve immune checkpoint inhibitor effectiveness.

Areas of Expertise

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Publications

Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration

Nguyen JT, Ray C, Fox AL, Mendonça DB, Kim JK, Krebsbach PH
Science Advances. 4(5): eaao5838, 2018. [ Journal Article ]

mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer

Nguyen JT, Haidar FS, Fox AL, Ray C, Mendonça DB, Kim JK, Krebsbach PH
iScience. 17: 190-207, 2019. [ Journal Article ]

MicroRNA-1911-3p targets mEAK-7 to suppress mTOR signaling in human lung cancer cells

Mendonça DB, Nguyen JT, Haidar F, Fox AL, Ray C, Amatullah H, Liu F, Kim JK, Krebsbach PH
Heliyon. 6(12): e05734, 2020. [ Journal Article ]

HPV32-related Heck's disease in a chronic graft-versus-host disease patient with long-term successful KTP laser treatment: A rare case report

Nguyen JT, Allen CT, Dodge JT, Van Doorslaer K, McBride AA, Pavletic SZ, Mays JW
Clinical Case Reports. 9(5): e04253, 2021. [ Journal Article ]

Conditional deletion of mTOR discloses its essential role in early B-cell development

Zhang S, Dubois W, Feng X, Nguyen JT, Young NS, Mock BA
Molecular Carcinogenesis. 61(4): 408-416, 2022. [ Journal Article ]

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