Breadcrumb

Joe T. Nguyen

Joe T. Nguyen, D.D.S., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Physician-Scientist Early Investigator
Surgical Oncology Program
NIH Distinguished Scholar

RESEARCH SUMMARY

Head and Neck Cancer (HNC) patients frequently exhibit amplifications and mutations within the PI3K/mTOR signaling pathway. The Nguyen Laboratory is dedicated to uncovering the intricate link between metabolism and its influence on the tumor immune microenvironment using advanced CRISPR/Cas9 gene editing, spatial multiomics bioinformatics analysis, molecular biology techniques. Through insights derived from patient data, we strive to enhance the accuracy of pre-clinical HNC models and drive our understanding of the pathobiology for the development of novel therapeutics to improve immune checkpoint inhibitor effectiveness.

Areas of Expertise

Information for Patients

Learn more about our clinical trials and the highly specialized care teams who lead them.

Publications

Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration

Nguyen JT, Ray C, Fox AL, Mendonça DB, Kim JK, Krebsbach PH
Science Advances. 4(5): eaao5838, 2018. [ Journal Article ]

mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer

Nguyen JT, Haidar FS, Fox AL, Ray C, Mendonça DB, Kim JK, Krebsbach PH
iScience. 17: 190-207, 2019. [ Journal Article ]

MicroRNA-1911-3p targets mEAK-7 to suppress mTOR signaling in human lung cancer cells

Mendonça DB, Nguyen JT, Haidar F, Fox AL, Ray C, Amatullah H, Liu F, Kim JK, Krebsbach PH
Heliyon. 6(12): e05734, 2020. [ Journal Article ]

HPV32-related Heck's disease in a chronic graft-versus-host disease patient with long-term successful KTP laser treatment: A rare case report

Nguyen JT, Allen CT, Dodge JT, Van Doorslaer K, McBride AA, Pavletic SZ, Mays JW
Clinical Case Reports. 9(5): e04253, 2021. [ Journal Article ]

Conditional deletion of mTOR discloses its essential role in early B-cell development

Zhang S, Dubois W, Feng X, Nguyen JT, Young NS, Mock BA
Molecular Carcinogenesis. 61(4): 408-416, 2022. [ Journal Article ]

Job Vacancies

We have no open positions in our group at this time, please check back later.

To see all available positions at CCR, take a look at our Careers page. You can also subscribe to receive CCR's latest job and training opportunities in your inbox.

News

Learn more about CCR research advances, new discoveries and more
on our news section.

Alumni

Karington perry
Karington Perry
2024
NIH CRI SIP
tina f
Tina Fung
2024
NIH SIP
Aimal Abid
Aimal Abid
2024
NIH HiSTEP2.0 SIP
L Adeniseum
Lovelace Adeniseun
2024
NIH SIP