Rosa Nguyen, M.D., Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10-CRC, Room 1-5816
- Bethesda, MD 20892
- 240-760-6104
- hongharosa.nguyen@nih.gov
RESEARCH SUMMARY
Dr. Nguyen is a pediatric oncologist and physician-scientist specializing in the discovery and preclinical development of immunotherapies for children with solid tumors, such as neuroblastoma. The goal of her research is to translate new and effective immunotherapies from the bench to the bedside and understand the immunologic mechanisms that underlie tumor response and immune evasion.
Areas of Expertise
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Rosa Nguyen, M.D., Ph.D.
Research
The goal of my laboratory is to apply cutting-edge experimental systems and methods to develop new immunotherapies for patients with solid tumors, such as neuroblastoma. I am committed to creating an environment in my laboratory where everyone has an equal opportunity to succeed. I believe that diversity is integral to fostering a productive work environment for scientific discovery and collaboration, and I look forward to serving as a mentor to students and post-doctoral fellows. My laboratory focuses on two main areas:
1. Harnessing tumor-targeting antibodies and NK cell activity in neuroblastoma
We design next-generation antibodies, such as immunocytokines, bispecific T-cell engagers, and antibody-drug conjugates, and assess their therapeutic activity and immunologic effect in preclinical models of neuroblastoma. The aim of our studies is to translate these new antibody formats into investigator-initiated clinical trials for children with neuroblastoma.
2. Optimizing cell-based immunotherapy for pediatric solid tumors
We performed preclinical optimization of a GPC2-targeting chimeric antigen receptor (CAR) T-cell therapy to treat neuroblastoma and brain tumors. This work will be translated into an investigator-initiated first-in-human clinical trial for patients with neuroblastoma in the Pediatric Oncology Branch. To further optimize CAR T-cell therapy, our laboratory leverages CAR engineering approaches and transgenic cytokines to augment CAR function in the tumor microenvironment. We use genome-wide CRISPR screens and next-generation sequencing to understand the mechanisms of tumor response to and evasion from adoptive T-cell therapy. Altogether, these efforts are geared toward finding new cellular therapies to treat children with solid tumors.
Publications
- Bibliography Link
- View Dr. Nguyen's Complete Bibliography at NCBI.
Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial
Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma
Biography
Rosa Nguyen, M.D., Ph.D.
I am a board-certified pediatric oncologist and completed my pediatric residency at the University of Maryland and my subspecialty training at St. Jude Children’s Research Hospital. I earned my Ph.D. in Biomedical Sciences from the University of Tennessee Health Science Center. Before starting my own research group in the Pediatric Oncology Branch at the National Cancer Institute, I trained as a postdoctoral fellow at the National Heart, Lung, and Blood Institute and the National Cancer Institute. My work has been funded by the Department of Defense, American Society of Clinical Oncology, St. Baldrick’s Foundation, Children’s Cancer Foundation, and Solving Kids’ Cancer Foundation.
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