Scott M. Norberg, D.O.

Center for Cancer Research
National Cancer Institute

Building 10, Room 3-3132
Bethesda, MD 20892
240-858-3303
scott.norberg@nih.gov

Associate Research Physician

Center for Immuno-Oncology

Head, Solid Tumor Cellular Therapy Group

Team Member Of:

Acting Co-Director, Center for Cancer Research

James L. Gulley, M.D., Ph.D.

gulleyj@mail.nih.gov

RESEARCH SUMMARY

Dr. Norberg researches the use of immunotherapy and cellular therapy for a variety of conditions including human papillomavirus-positive (HPV+) cancers and premalignant diseases caused by chronic HPV infection. His research focuses on understanding resistance to immunotherapy and cellular therapies and applying these treatment modalities to other conditions.

Areas of Expertise

Colon and Rectal Cancer

Cell Therapy

Immunotherapy

Human Papillomavirus

Cervical Cancer

Oropharyngeal Cancer

Clinical Trials
Research
Publications
Biography
Team
News

Open - Recruiting

Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)

Protocol ID
IRB001572

Investigator

Scott M. Norberg, D.O.

Referral Contacts

Melissa Wheatley

240-858-3391
Open - Recruiting

T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

Protocol ID
000045

Investigator

Scott M. Norberg, D.O.

Referral Contacts

Parsons-wandell, Laura Ann
Open - Recruiting

E7 TCR T Cells for Human Papillomavirus-Associated Cancers

Protocol ID
16-C-0154

Investigator

Scott M. Norberg, D.O.

Referral Contacts

Parsons-wandell, Laura Ann
Open - Recruiting

Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

Protocol ID
16-C-0138

Investigator

Scott M. Norberg, D.O.

Referral Contacts

Parsons-wandell, Laura Ann
Open - Recruiting

Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols

Protocol ID
16-C-0061

Investigator

Scott M. Norberg, D.O.

Referral Contacts

Parsons-wandell, Laura Ann
Open - Not yet Recruiting
Summary Not Yet Available. Call Referral Contact.
Long-Term Follow Up for Subjects Treated with Gene Therapy Cell Products at Rutgers Cancer Institute

Protocol ID
IRB001805

Investigator

Scott M. Norberg, D.O.

Referral Contacts

NCI Medical Oncology Referral Office

888-624-1937

Research

Dr. Norberg conducts clinical research to develop T cell therapies for the treatment of patients with cancer and precancerous diseases. This includes conducting clinical trials using genetically engineered T cells to treat patients with advanced human papillomavirus (HPV) malignancies.

Publications

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanovic S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, Astrow SH, Bot A, Faquin WC, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS.

Nat Med. 2021.

Full-Text Article

[ Journal Article ]

Cancer targeting by TCR gene-engineered T cells directed against Kita-Kyushu Lung Cancer Antigen-1

Marcinkowski B, Stevanović S, Helman SR, Norberg SM, Serna C, Jin B, Gkitsas N, Kadakia T, Warner A, Davis JL, Rooper L, Hinrichs CS.

J Immunother Cancer. 7(1): 229, 2019. [ Journal Article ]

Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis

Allen CT, Lee S, Norberg SM, Kovalovsky D, Ye H, Clavijo PE, Hu-Lieskovan S, Schlegel R, Schlom J, Strauss J, Gulley JL, Trepel J, Hinrichs CS.

J Immunother Cancer. 7(1): 119, 2019. [ Journal Article ]

Advances in Adoptive Cell Therapy for Head and Neck Cancer

Scott M Norberg, Christian S Hinrichs

Otolaryngol Clin North Am. Aug;54(4): 761-768, 2021. [ Journal Article ]

Dual PD-L1 and TGF-b blockade in patients with recurrent respiratory papillomatosis

Yvette Robbins, Jay Friedman, Paul E Clavijo, Cem Sievers, Ke Bai, Renee N Donahue, Jeffrey Schlom, Andrew Sinkoe, Christian S Hinrichs, Clint Allen, Houssein Abdul Sater, James L Gulley, Scott Norberg

J Immunother Cancer. Aug;9(8): e003113, 2021. [ Journal Article ]

Biography

Associate Research Physician

Scott M. Norberg, D.O.

span data-style="font-size:14px;">Dr. Norberg received his B.S. from Saint Mary’s College of California and a M.S. in Medical Sciences at Drexel University. He received his medical degree at the Philadelphia College of Osteopathic Medicine. He completed his residency in internal medicine at Temple University Hospital and a fellowship in medical oncology at the National Cancer Institute. After fellowship training, he joined the research group of Dr. Christian Hinrichs where he conducts clinical research to develop T-cell therapies for patients with malignant and premalignant disease.

Dr. Norberg is board certified in internal medicine and medical oncology.