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Zhi-Ming Zheng, M.D., Ph.D.

Zhi-Ming Zheng, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Head, Tumor Virus RNA Biology Section

RESEARCH SUMMARY

Dr. Zheng first identified RNA cis-elements in regulation of alternative RNA splicing in papillomavirus in 1996 and has been studying protein-RNA interactions and their consequences in various infections with tumor viruses, including high-risk human papillomaviruses and Kaposi’s sarcoma-associated herpesvirus. This study aims to understand how RNA splicing and non-coding RNAs regulate the expression of viral and host genes in viral carcinogenesis. The long-term goal is to develop a series of therapeutic approaches to control viral or cellular gene expression for cancer or AIDS treatments and to identify biomarkers for clinical diagnosis and prognosis.

Areas of Expertise

RNA Processing
RNA-Protein Interactions
Regulatory RNAs
Tumor Viruses

Publications

Selected Recent Publications

HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer

Yu L, Majerciak V, Lobanov A, Mirza S, Band V, Liu H, Cam M, Hughes SH, Lowy DR, Zheng ZM.
mBio. 15(5): e0072924., 2024.
Full-Text Article
[ Journal Article ]

RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules

Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM
Nucleic Acids Res . 51: 9337-9355, 2023.
Full-Text Article
[ Journal Article ]

Oncogenic SRSF3 in health and diseases

Jia R, Zheng ZM
Int J Biol Sci. 19: 3057-3076, 2023.
Full-Text Article
[ Journal Article ]

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57

Majerciak V, Alvarado-Hernandez B, Lobanov A, Cam M, Zheng ZM
PLoS Pathog. 18(7): e1010311, 2022.
Full-Text Article
[ Journal Article ]

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News

Poster Presentations at NCI Frederick Summer Poster Day 2024

Sissi Zhang (summer intern) and Angelika Chen (Werner H. Kirsten Student Intern) who are being mentored by Deanna Gotte and Ayslan Castro Brant, respectively, showcased their research to the wider NCI Frederick community at the summer poster day (2024).

Lulu Yu mBio paper was selected as paper of the week by the International Papillomavirus Society. 

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Lulu Yu paper of the week

Congratulations to our NIH Fellows Award for Research Excellence (FARE) 2023 winner: Dr. Ayslan Brant 

Ayslan Brant

Dr. Ayslan Brant

Congratulations to our NIH Fellows Award for Research Excellence (FARE) 2023 winner: Dr. Lulu Yu. 

Congratulations to our 2022 DRP Think Tank winner: Dr. Lulu Yu

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Dr. Lulu Yu

Congratulations to our NIH Fellows Award for Research Excellence (FARE) 2022 winner: Dr. Beatriz Alvarado Hernandez

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​ Image Photo of Beatriz Alvarado Hernandez

Beatriz Alvarado Hernandez

Congratulations to our 2021 DRP Think Tank winner: Dr. Haibin Liu

Dr. Haibin Liu

 

Congratulations to our 2020 ASV Travel Award recipients:  Dr. Haibin Liu, Dr. Lulu Yu, and Dr. Beatriz Alvarado Hernandez

 

 

Congratulations to our 2020 CCR HIV & Cancer Virology Think Tank Meeting Travel Award recipient: Dr. Beatriz Alvarado Hernandez

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Photo of Beatriz Alvarado Hernandez

Beatriz Alvarado Hernandez CRTA - Best Oral Presentation at the 2020 CCR HIV & Cancer Virology Think Tank Meeting