Interested in Joining?
If you are an NCI Principal Investigator and are interested in joining the NCI RNA Biology Initiative, please contact Sandra Wolin, Meredith Metzger or any member of the Steering Committee.
| Name | Interests/Expertise | ||
|---|---|---|---|
| Adhya, Sankar | nucleoid structure and modulation of transcription by DNA control elements and regulatory proteins | ||
| Aregger, Michael | understanding how cancer cells rewire gene expression and metabolism in order to adapt to changing environmental conditions | ||
| Banday, Rouf | RNA-sensing mechanisms and immunity, RNA splicing alterations in cancer | ||
| Batista, Pedro | understanding how the RNA epigenome modulates gene expression during development and in disease | ||
| Caplan, Natasha | 1) understanding of the RNAi mechanism, 2) development of optimized RNAi-based resources, and protocols and assays using them, and 3) application of RNAi to cancer and cancer-related processes and the use of RNAi to investigate the mechanism of action of anticancer drugs and their interaction with specific molecular target(s) | ||
| Felber, Barbara | utilizing retroviral systems to identify and study mechanisms of mRNA metabolism using a combination of biochemistry, functional genomics, and proteomics; RNA optimized gag and env expression vectors for DNA vaccines | ||
| Franchini, Veffa | mRNA in T-cell transformation by oncoviruses | ||
| Freed, Eric | HIV/retrovirus assembly, viral protein trafficking, retrovirus replication, HIV-1 maturation | ||
| Gonatopoulos-Pournatzis, Thomas | 1) alternative splicing, 2) RNA biology, 3) gene regulation, 4) genome engineering, 5) CRISPR-Cas, 6) functional genomics | ||
| Gottesman, Susan | small regulatory RNAs and energy-dependent proteolysis: novel modes for the regulation of gene expression | ||
| Grewal, Shiv | RNAi role in targeting of heterochromatin complexes to specific locations in the genome | ||
| Gu, Shuo | RNA-induced silencing complex assembly; novel design of potent DNA-directed RNAi (shRNA) with minimal off-target effects; fidelity of miRNA biogenesis - dissecting Dicer processing in vivo | ||
| Hannenhalli, Sridhar | 1) bioinformatics, 2) transcriptional regulation, 3) single cell omics, 4) cancer genomics | ||
| Harris, Curt | profiles of miRNAs and inflammation genes as they relate to cancer diagnosis, prognosis and therapeutic outcome | ||
| Hoang, Chuong | translating deranged microRNA profiles unique to mesothelioma and other thoracic cancers for biomarker discovery and novel therapeutic strategies | ||
| Hu, Wei-Shau | understanding retroviral Gag and RNA targeting and virus assembly; reverse transcription and recombination; regulation of retroviral RNA packaging and dynamics of HIV-1 RNA export | ||
| Hu, Yinling | understanding the regulatory function of stress granules-membrane-less liquid body organelles containing RNAs and RNA binding proteins in carcinogenesis | ||
| Huang, Jing | role of long non-coding RNAs in ES cells | ||
| Ji, Xinhua | structural view of RNA processing | ||
| Johnson, Peter | 3'UTR-mediated regulation of mRNA localization and protein activity; signaling; transcription factors | ||
| Kaplan, Rosandra | bone marrow-derived cells and specific regulation of gene expression in the pre-metastatic niche | ||
| Kashlev, Mikhail | direct assessment of transcription fidelity by high-resolution RNA sequencing; mechanisms of transcription through chromatin by RNA polymerase II and III; determinants of RNA polymerase processivity in transcription elongation; DNA-protein and DNA-RNA interactions in elongation complex of RNA polymerase | ||
| KewalRamani, Vineet | role of host factors in HIV infection and the biology of HIV in animal models | ||
| Khan, Javed | next-generation sequencing, RNAseq, gene expression profiling, downstream effects of fusion genes, alternative splicing | ||
| Lal, Ashish | non-coding RNAs in p53 signaling; role of long non-coding RNAs during DNA damage | ||
| Larson, Dan | transcription dynamics in single cells; gene expression profiling and RNA visualization with single-molecule FISH | ||
| Lazzerini Denchi, Eros | nonsense-mediated decay (NMD) in telomere maintenance | ||
| Luo, Ji | pooled shRNA screens for target discoveries in cancer; alternative splicing in Ras-transformed cells; new shRNA vectors for mammalian genetic analysis | ||
| Meier, Jordan | chemical biology, assay design, epitranscriptomics | ||
| Meltzer, Paul | the role of sequence-based methods in cancer genome profiling | ||
| Mili, Voula | RNA localization, localized translation, disruption of RNA localization pathways in disease | ||
| Misteli, Tom | RNA biogenesis, alternative pre-mRNA splicing, chromatin in RNA processing, RNAs in living cells, splicing and disease | ||
| Name | research interests/expertise | |
|---|---|---|
| O'Keefe, Barry | discovery and characterization of novel antiviral proteins from natural products extracts | |
| Oberdoerffer, Shalini | regulation of alternative pre-mRNA splicing through RNA binding proteins and chromatin modifications | |
| Pathak, Vinay | nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes | |
| Rein, Alan | mechanisms in retroviral replication and pthogenesis; packaging of viral RNA | |
| Savage, Sharon | telomere molecular epidemiology; understanding cancer etiology - osteosarcoma; Li-Fraumeni syndrome | |
| Schneider, Thomas | theoretical work on E. coli ribosome binding sites, RNA polymerase initiation, and human splice junctions | |
| Schneekloth, Jay | identification of RNA-binding small molecules with small molecule microarrays | |
| Shern, Jack | 1) rhabdomyosarcoma, 2) fusion oncogenes, 3) precision medicine, 4) whole genome sequencing, 5) RNA sequencing, 6) epigenetics | |
| Singer, Dinah | TAF7: a check-point regulator in transcription initiation; Brd4 is an atypical kinase that regulates transcription | |
| Staudt, Lou | RNA interference-based screens for molecular targets in cancer/molecular diagnosis and outcome prediction in lymphoma | |
| Stewart, Douglas | adult manifestations of RAS-pathway disorders (especially NF1 and Legius syndrome); next generation sequencing of NF1-associated tumors; characterization of novel features of NF1; pleuropulmonary blastoma (PPB) DICER1 cancer | |
| Tessarollo, Lino | research is focused on signaling of neurotrophins and their Trk receptors in development and disease | |
| Valkov, Eugene | 1) biochemical reconstitution, 2) RNA decay and surveillance pathways, 3) translational control, 4) integrative structural analysis, 5) RNA-binding proteins, 6) biomolecular interactions | |
| Vidigal, Joana | functional dissection of small noncoding RNAs; regulation and function of RNA binding proteins (RBPs); CRISPR tools to dissect RNA pathways | |
| Wang, Yun-Xing | to understand the fundamental interactions regulating essential events involving RNA in the translational and post-translational processes on both the structural and cellular levels | |
| Wang, Xin | determine the role of small non-coding RNAs (e.g., microRNAs) in hepatocellular carcinoma metastases, recurrence, survival and gender disparity | |
| Wolin, Sandra | biogenesis and functions of noncoding RNAs and RNPs; RNA surveillance | |
| Wu, Colin | translational control of gene expression; RNA quality control | |
| Zhang, Ying | molecular mechanisms of TGF-beta signaling pathway; physiological and pathological functions of E3 ubiquitin ligases Smurfs | |
| Zheng, Thomas | RNA-protein interaction in regulation of alternative RNA splicing and miRNA expression and function | |
| Zhurkin, Victor | p53-induced regulation of transcription in the chromatin context; DNA folding in chromatin and interaction with transcription factors | |
| Ziegelbauer, Joe | functions of viral microRNAs; expression profiling (mRNA/protein) with gain/loss of miRNA function | |